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Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality
Alzheimer disease is a neurodegenerative disease characterized by the presence of senile plaques composed of amyloid-β (Aβ) peptide, neurofibrillary tangles, neuronal loss and neuroinflammation. Previous works have revealed that extracellular ATP, through its selective receptor P2X7 (P2X7R), is essential to neuroinflammation and neurotoxicity induced by Aβ.
MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology After Status Epilepticus
Prolonged seizures (status epilepticus) may drive hippocampal dysfunction and epileptogenesis, at least partly, through an elevation in neurogenesis, dysregulation of migration and aberrant dendritic arborization of newly-formed neurons. MicroRNA-22 was recently found to protect against the development of epileptic foci, but the mechanisms remain incompletely understood.
The regulation of proteostasis in glial cells by nucleotide receptors is key in acute neuroinflammation | The FASEB Journal
The disturbances of cellular proteostasis caused by the alteration in the ubiquitin-proteasome system (UPS) have been proposed as a common mechanism underlying several neural pathologies that involve a neuroinflammatory process. As we have previously reported that the nucleotide receptor P2Y purinoceptor 2 (P2Y 2R) regulates the proteasomal catalytic activities, we wonder whether this receptor is involved in the UPS disturbances associated with the neuroinflammation process.
A novel BAC transgenic mouse model reveals glial restriction of P2X7 expression in the central and peripheral nervous systems.
Changes in the activity of microglia, the primary immune cells of the central nervous system, are linked with major human diseases, including stroke, epilepsy, psychiatric disorders, and neurodegeneration. Cserép et al. identified a specialized morphofunctional communication site between microglial processes and neuronal cell bodies in the mouse and the human brain (see the Perspective by Nimmerjahn).
News & Events
PurinesDX PhD candidate Francesco Calzaferri talks about his research project for the Spanish Society of Pharmacology.
PhD position in the frame of the newly funded SFB 1328 “Adenine nucleotides in immunity and inflammation”
Prof Annette Nicke at Ludwig Maximillians University is looking for a PhD candidate to join her group in Munich: We offer an exciting research project aiming to identify the cell-specific expression, signalling and (patho-)physiological functions of...
PurinesDX project coordinator Dr Tobias Engel is looking for a postdoctoral fellow with experience in whole cell patch-clamp. The research group of Dr. Engel at the Department of Physiology and Medical Physics (RCSI) investigates...
Nearly 300 young researchers from all over the world have submitted their application to one of the 14 projects at the PurinesDX network. The projects are centered around understanding the role of purinergic receptors...
The project (PurinesDX) has received funding of over €3.5 million from the European Commission’s Horizon 2020 Research and Innovation Framework Programme aims to train the next generation of specialists in purinergic signalling during brain...