PhD position in the frame of the newly funded SFB 1328 “Adenine nucleotides in immunity and inflammation”
We offer an exciting research project aiming to identify the cell-specific expression, signalling and (patho-)physiological functions of the P2X7 receptor in a novel P2X7-EGFP BAC transgenic mouse model (Kaczmarek-Hájek, Zhang, Stocklauser et al., eLife, 2018).
P2X receptors represent a class of ATP-gated ion channels that are present in virtually all mammalian tissues and mediate a large variety of responses ranging from fast neurotransmission to proliferation and cell death. Their importance as novel drug targets (e.g. for the treatment of pain and inflammatory processes) is increasingly becoming apparent. Activation of the P2X7 receptor subtype mediates a variety of effects (e.g. cytokine secretion, cell morphology changes, apoptosis) that are incompletely understood. In this project we are aiming at understanding the molecular and physiological mechanisms of P2X7 receptor activation and signaling with a focus on the central and peripheral nervous system.
Close interaction with and possibility to attend lectures in other research consortia (e.g. Purines DX) will be possible.
We are looking for a highly motivated person with enthusiasm for basic science and a good back¬ground in molecular biology/biochemistry. Experience in work with genetically modified mice, -omics approaches or confocal microsopy is an advantage. The ability to independently and responsibly plan and perform experiments and to work in an international team is expected.
Please send your application including a letter of motivation, CV, certificates, and references until Sept. 14, 2018 to:
Prof. Dr. Annette Nicke
Walther-Straub-Institute for Pharmacology und Toxicology