Prof Annette Nicke

Work Package 1 Leader

Department of Pharmacology and Toxicology, University Ludwig Maximilians

Laboratory of Molecular Toxicology


Project 3




1989-1993: Degree in Pharmacy at the J. W. Goethe-University Frankfurt

1993-1994: Internship in a public pharmacy and in the Central Research and Develop­ment Division, Dept. of Biotechnology, Bayer Company, Leverkusen, Approbation as a Pharmacist

1995-1999: PhD thesis with Prof. Dr. Dr. Dres. h.c. E. Mutschler and Prof. Dr. G. Schmalzing at the Institute of Pharma­cology, Uni­ver­sity of Frankfurt “Determination of the quaternary structure of the P2X receptor”

1995-1998: DFG Graduate School Fellowship

1999-2000: DFG Graduate School Postdoc Fellowship at the Institute of Pharmacology, University of Frankfurt

2000: Research project in the group of Dr. J. Wess at the National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA

2000-2003: Postdoc at the Institute for Molecular Bioscience, Centre for Drug Design and Development in Brisbane, Australia “Structure activity relationship of a-conotoxins”

2001-2002: Emmy Noether Fellow­ship of the DFG

2003: Postdoc at the Max-Planck-Institute for Experimental Medicine, Göttingen

2003-2009: Project group leader at the Max-Planck-Institute for Brain Research, Dept. of Neurochemistry, Frankfurt

2008-2013: Heisenberg-fellow of the DFG “Generation of P2X transgenic mouse models”

2010-2013: Project group leader at the Max-Planck-Institute for Experimental Medicine, Göttingen

July 2010: Habilitation University of Frankfurt “Investigation of the oligomerization and ligand binding of neurotransmitter-gated ion channels”

Since 2013: Professor of Molecular Toxicology and Pharmacology, Ludwig Maximilians University, Munich


Research interests

1) Molecular structure and function of P2X receptors

2) Analysis of the expression patterns, protein interactions and physiological functions of P2X7 receptors using BAC transgenic mice

3) Structure-activity analysis of a-conotoxins and nicotine receptor modulators


About Ludwig-Maximilians University

The Walther Straub Institute of Pharmacology and Toxicology has been named after the German pharmacologist Walther Straub who led the institute from 1924 to 1944. It is located in two locations (Goethestraße 33 and Nussbaumstraße 26) close to the Munich main station and the LMU university hospitals in the inner city of Munich.

Research in the WSI concentrates on interdisciplinary aspects of basic research in pharmacology and toxicology with a focus on ion channel research.

It belongs to the theoretical research institutes of the Medical Faculty. The institute is involved in teaching of students of medicine and dental medicine as well as life sciences.