Work Package 1 Leader
Department of Pharmacology and Toxicology, University Ludwig Maximilians
Laboratory of Molecular Toxicology
Project 3
contact: annette.nicke@lrz.uni-muenchen.de
Biography
1989-1993: Degree in Pharmacy at the J. W. Goethe-University Frankfurt
1993-1994: Internship in a public pharmacy and in the Central Research and Development Division, Dept. of Biotechnology, Bayer Company, Leverkusen, Approbation as a Pharmacist
1995-1999: PhD thesis with Prof. Dr. Dr. Dres. h.c. E. Mutschler and Prof. Dr. G. Schmalzing at the Institute of Pharmacology, University of Frankfurt “Determination of the quaternary structure of the P2X receptor”
1995-1998: DFG Graduate School Fellowship
1999-2000: DFG Graduate School Postdoc Fellowship at the Institute of Pharmacology, University of Frankfurt
2000: Research project in the group of Dr. J. Wess at the National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA
2000-2003: Postdoc at the Institute for Molecular Bioscience, Centre for Drug Design and Development in Brisbane, Australia “Structure activity relationship of a-conotoxins”
2001-2002: Emmy Noether Fellowship of the DFG
2003: Postdoc at the Max-Planck-Institute for Experimental Medicine, Göttingen
2003-2009: Project group leader at the Max-Planck-Institute for Brain Research, Dept. of Neurochemistry, Frankfurt
2008-2013: Heisenberg-fellow of the DFG “Generation of P2X transgenic mouse models”
2010-2013: Project group leader at the Max-Planck-Institute for Experimental Medicine, Göttingen
July 2010: Habilitation University of Frankfurt “Investigation of the oligomerization and ligand binding of neurotransmitter-gated ion channels”
Since 2013: Professor of Molecular Toxicology and Pharmacology, Ludwig Maximilians University, Munich
Research interests
1) Molecular structure and function of P2X receptors
2) Analysis of the expression patterns, protein interactions and physiological functions of P2X7 receptors using BAC transgenic mice
3) Structure-activity analysis of a-conotoxins and nicotine receptor modulators
About Ludwig-Maximilians University
The Walther Straub Institute of Pharmacology and Toxicology has been named after the German pharmacologist Walther Straub who led the institute from 1924 to 1944. It is located in two locations (Goethestraße 33 and Nussbaumstraße 26) close to the Munich main station and the LMU university hospitals in the inner city of Munich.
Research in the WSI concentrates on interdisciplinary aspects of basic research in pharmacology and toxicology with a focus on ion channel research.
It belongs to the theoretical research institutes of the Medical Faculty. The institute is involved in teaching of students of medicine and dental medicine as well as life sciences.
