Prof Miguel Diaz-Hernandez


Training Committee Chair

Department of Biochemistry and Molecular Biology

University Complutense Madrid 

Projects 4 and 5




My doctoral training from 1996 to 2002 in University Complutense of Madrid was focused to study the molecular mechanisms by which purinergic receptors modulate synaptic plasticity. Resulting from these studies I contributed to more than 14 scientific publications.

After working in St. Louis University, USA in 2001 and Max-Planck Institute in Göttinguen, Germany in 2002, I started my training at the CBMSO in October 2002. There I began to study the molecular mechanisms that are affected in different neurodegenerative diseases, focusing initially on Huntington’s disease (Díaz-Hernández et al., 2003, 2004 and 2005 J. Neurosci)

With these roots, my scientific restlessness made me question whether alterations in purinergic transmission were one of the common molecular mechanisms that underlie neurodegenerative diseases. Thanks to the obtaining of a contract Juan de la Cierva (2005-2008) and later of a Ramón y Cajal contract (2008-2009), I was able to develop my first studies aimed at this end (Diaz-Hernández et al. 2009, FASEB journal).

Since October 2009, when I obtained my position as a professor at the Complutense University, I lead a research group whose primary objective is to identify the molecular mechanisms that underlie neurodegenerative diseases to find new pharmacological targets. Thus, we have identified possible new pharmacological targets to treat Alzheimer’s disease (Diaz-Hernández et al 2010, JBC, Diaz-Hernández et al 2012, Neurobiology of aging), seizures (Engel et al., 2012 FASEB Journal; Sebastian -Serrano et al 2016, Human Molecular Genetic), or neuroinflammation associated with neurodegenerative processes (de Diego-Garcia et al 2017).


About University Complutense Madrid

Universidad Complutense de Madrid (UCM) is the largest public university in Spain with more than 85,000 students distributed among 21 faculties. UCM is the home to 575 research groups integrated by more than 6,000 researchers and with an annual budget of almost 600M€.

Besides faculties and institutes, the institution comprises a full repertoire of core facilities, including those for genomic and transcriptome large-scale sequencing, NMR and microscopy imaging and biobanking. The Faculty of Veterinary Medicine occupies the second position in the ranking of UCM faculties according to their research budget, which comes from both public and private funding sources, representing 11.75% of the research budget of UCM including the Department of Biochemistry and Molecular Biology to which Prof. Díaz-Hernández is a member.

Students enrolled at UCM can avail of courses from the master’s degrees in the University, in addition to available PhD specific courses: Mathematical Analysis of Biological Data, Seminar Series, Communication and Dissemination of Research Seminar, Development of a Scientific Publication, Presentation of Research Skills. Skills in scientific comprehension, research skills, critical data analysis, academic and public communication of scientific research, decision making, research in a multidisciplinary and international context and self-criticism complete the list ( and