Projects

Project 1

Identification of the cell-specific contribution of the P2X7 receptor to seizure-induced pathology and epilepsy development

PhD candidate: James Morgan

Project Supervisor: Dr Tobias Engel

Collaborators: Prof Felix Rosenow, Dr John Ryan and Prof Miguel Diaz-Hernandez

Location: Royal College of Surgeons in Ireland

Project 2

P2X7 receptor signalling during seizures and identification of a seizure-specific P2X7R signature in blood

PhD candidate: Giorgia Conte

Project Supervisor: Dr Tobias Engel

Collaborators: Prof Annette Nicke, Prof Nicholas Dale and Prof Felix Rosenow

Location: Royal College of Surgeons in Ireland

Project 3

Identification of novel disease-specific P2X7R down-stream targets in schizophrenia and epilepsy

PhD candidate: Antonio Ramirez-Fernandez

Project Supervisor: Prof Annette Nicke

Collaborators: Prof Antonio Garcia, Dr Tobias Engel and Prof Beata Sperlagh

Location: University of Ludwig Maximilans, Germany

Project 4

Targeting of the purinergic P2X7 receptor to treat Alzheimer’s disease

PhD candidate: Caterina Di Lauro

Project Supervisor: Prof Miguel Diaz-Hernandez

Collaborators: Dr Miguel Medina, Dr Tobias Engel and Prof Andras Dinnyes

Location: University Complutense Madrid, Spain

Project 5

Blood purines as novel diagnostic for pre-clinical Alzheimer’s disease and identification of P2X7R-dependent down-stream targets in Alzheimer’s disease

PhD candidate: Carolina Bianchi

Project Supervisor: Prof Miguel Diaz-Hernandez

Collaborators: Dr Tobias Engel, Dr Miguel Medina and Dr Benjamin Seibt

Location: University Complutense Madrid, Spain

Project 6

P2X7R signalling in the brain during schizophrenia and blood purine changes as novel diagnostics and prognostics for schizophrenia

PhD candidate: Lumei Huang

Project Supervisor: Prof Beata Sperlagh

Collaborators: Prof Nicholas Dale, Prof Istvan Bitter and Prof Miguel Diaz-Hernandez

Location: Institute of Experimental Medicine, Hungarian Academy of Sciences, Hungary

Project 7

Pathological contribution of the ATP-gated purinergic P2X7 receptor to the pathogenesis of schizophrenia

PhD candidate: Paula Mut Arbona

Project Supervisor: Prof Beata Sperlagh

Collaborators: Prof Istvan Bitter, Prof Jose Lucas and Prof Antonio Garcia

Location: Institute of Experimental Medicine, Hungarian Academy of Sciences, Hungary

Project 8

The P2X7 receptor as drug target in depression and blood purines as novel diagnostic and prognostics in depression

PhD candidate: Lidia Urbina

Project Supervisor: Dr Jan Deussing

Collaborators: Prof Martin E Keck, Prof Beata Sperlagh and Dr Benjamin Seibt

Location: Max Planck Institute of Psychiatry, Germany

Project 9

The purinergic P2X7 receptor in diagnosis, prognosis and treatment in Huntington’s disease

PhD candidate: Ivana Ollà

Project Supervisor: Prof Jose Lucas

Collaborators: Dr Jose Lopez, Dr Benjamin Seibt and Dr Tobias Engel

Location: Networking Research Center on Neurodegenerative Diseases Center for Molecular Biology (CIBERNED), Spain

Project 10

Analysis of P2X7 receptor function and effects of P2X7R antagonism on neuronal differentiation and connectivity in neuronal networks generated from Alzheimer’s disease patient derived pluripotent stem cells

PhD candidate: Linda Francistiova

Project Supervisor: Prof Andras Dinnyes

Collaborators: Dr Miguel Medina, Dr Tobias Engel and Prof Annette Nicke

Location: Bio Talentum, Hungary

Project 11

Development of a novel in vivo biosensor for neuroscience applications

PhD candidate: Martina Mengoni

Project Supervisor: Prof Nicholas Dale

Collaborators: Dr Tobias Engel, Prof Felix Rosenow and Dr Miguel Medina

Location: Sarissa Biomedical LTD, UK

Project 12

Biosensor approaches to the study of purinergic signalling during acute and chronic brain diseases

PhD candidate: Monica Garcia Durillo

Project Supervisor: Prof Bruno Frenguelli

Collaborators: Dr Tobias Engel, Prof Beata Sperlagh and Prof Andras Dinnyes

Location: Sarissa Biomedical LTD, UK

Project 13

The ATP-gated P2X7 receptor as novel treatment target in amyotrophic lateral sclerosis

PhD candidate: Cristina Ruiz

Project Supervisor: Prof Antonio Garcia

Collaborators: Prof Miguel Diaz-Hernandez, Dr Tobias Engel and Prof Beata Sperlagh

Location: Foundation Teofilo Hernando, Spain

Project 14

Development of a novel blood brain barrier and brain stable P2X7R antagonist

PhD candidate: Francesco Calzaferri

Project Supervisor: Prof Antonio Garcia

Collaborators: Prof Annette Nicke, Dr Jan Deussing and Prof Andras Dinnyes

Location: Foundation Teofilo Hernando, Spain