Publications

2018

Alves M, Beamer E & Engel T (2018) The metabotropic purinergic P2Y receptor family as novel drug target in epilepsy. Front Pharmacol 9: 193. Link to paper here.

Beamer EH, Jurado-Arjona J, Jimenez-Mateos EM, Morgan J, Reschke CR, Kenny A, de Leo G, Olivos-Ore LA, Arribas-Blazquez M, Madden SF, Merchan-Rubira J, Delanty N, Farrell MA, O’Brien DF, Avila J, Diaz-Hernandez M, Miras-Portugal MT, Artalejo AR, Hernandez F, Henshall DC & Engel T (2018) MicroRNA-22 controls aberrant neurogenesis and changes in neuronal morphology after status epilepticusFront Mol Neurosci https://doi.org/10.3389/fnmol.2018.00442. Link to paper here.

de Diego García L, Sebastián-Serrano A, Hernández IH, Pintor J, Lucas JJ & Díaz-Hernández M (2018) The regulation of proteostasis in glial cells by nucleotide receptors is key in acute neuroinflammation. FASEB J 32(6):3020-3032. Link to paper here.

Engel T, Gómez-Sintes R, Alves M, Jimenez-Mateos EM, Fernández-Nogales M, Sanz-Rodriguez A, Morgan J, Beamer E, Rodríguez-Matellán A, Dunleavy M, Sano T, Avila J, Medina M, Hernandez F, Lucas JJ & Henshall DC (2018) Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus. Cell Death Dis 9(10): 969. Link to paper here.

Hinz S, Navarro G, Borroto-Escuela D, Seibt BF, Ammon YC, de Filippo E, Danish A, Lacher SK, Červinková B, Rafehi M, Fuxe K, Schiedel AC, Franco R, Müller CE (2018) Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors. Oncotarget 9(17): 13593-13611. Link to paper here.

Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, Magnus T, Stadelmann C, Sirko S, Koch-Nolte F, Eulenburg V & Nicke A (2018) Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody. eLife 7: e36217. Link to paper here.

Sebastián-Serrano A, de Diego-García L, Henshall DC, Engel T & Díaz-Hernández M (2018) Haploinsufficient TNAP mice display decreased extracellular ATP levels and expression of Pannexin-1 channels. Front Pharmacol 9: 170. Link to paper here.

Stephan G, Huang L, Tang Y, Vilotti S, Fabbretti E, Yu Y, Nörenberg W, Franke H, Gölöncsér F, Sperlágh B, Dopychai A, Hausmann R, Schmalzing G, Rubini P & Illes P (2018) The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel. Nat Commun 9(1):1354. Link to paper here.

 

2017

Beamer E, Kovács G & Sperlágh B (2017) ATP released from astrocytes modulates action potential threshold and spontaneous excitatory postsynaptic currents in the neonatal rat prefrontal cortex. Brain Res Bull 135:129-142. Link to paper here.

Deussing JM (2017) Heterozygosity for the mood disorder-associated variant Gln460Arg alters P2X7 receptor function and sleep quality.  J Neurosci 37(48): 11688-11700. Link to paper here.

Gölöncsér F, Baranyi M, Balázsfi D, Demeter K, Haller J, Freund TFF, Zelena D & Sperlágh B (2017) Regulation of hippocampal 5-HT release by P2X7 receptors in response to optogenetic stimulation of median raphe terminals of mice. Front Mol Neurosci 10:325. Link to paper here.

Kovács G, Környei Z, Tóth K, Baranyi M, Brunner J, Neubrandt M, Dénes Á & Sperlágh B Modulation of P2X7 purinergic receptor activity by extracellular Zn2+ in cultured mouse hippocampal astroglia. Cell Calcium 75:1-13. Link to paper here.

Otrokocsi L, Kittel Á & Sperlágh B (2017) P2X7 receptors drive spine synapse plasticity in the learned helplessness model of depression. Int J Neuropsychopharmacol 20(10):813-822. Link to paper here.